Neurobiology of Disease Decreased Brain-Derived Neurotrophic Factor Depends on Amyloid Aggregation State in Transgenic Mouse Models of Alzheimer’s Disease
نویسندگان
چکیده
Shiyong Peng,1 Diego J. Garzon,1 Monica Marchese,1 William Klein,2,3 Stephen D. Ginsberg,4 Beverly M. Francis,5,6 Howard T. J. Mount,5,6 Elliott J. Mufson,7 Ahmad Salehi,8 and Margaret Fahnestock1 1Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario L8N 3Z5, Canada, 2Institute for Neuroscience, Northwestern University, Evanston, Illinois 60611, 3Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, 4Nathan Kline Institute, New York University School of Medicine, Orangeburg, New York 10962, 5Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario M5S 3H2, Canada, 6Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada, 7Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, and 8Department of Neurology, Stanford University, Stanford, California 94305
منابع مشابه
P97: Physical Exercise as an Effective Factor in Alzheimer Disease
Alzheimer's disease (AD) is a progressive disease that destroys memory and other important mental activities. Scientists have found that remaining relatively active can lead to better brain activities in those at risk of developing AD. In some Meta-analyses of prospective investigations, a significantly reduced risk of dementia related to midlife exercise have been proven. Most studies have bee...
متن کامل3xTgAD mice exhibit altered behavior and elevated Aβ after chronic mild social stress.
Chronic stress may be a risk factor for developing Alzheimer's disease (AD), but most studies of the effects of stress in models of AD utilize acute adverse stressors of questionable clinical relevance. The goal of this work was to determine how chronic psychosocial stress affects behavioral and pathological outcomes in an animal model of AD, and to elucidate underlying mechanisms. A triple-tra...
متن کاملCholinergic neuropathology in a mouse model of Alzheimer's disease
Transgenic mice over-expressing mutant human amyloid precursor protein (PDAPP mouse) develop several Alzheimer’s disease (AD)-like lesions including an age-related accumulation of amyloid-?-containing neuritic plaques. Although aged, heterozygous PDAPP mice also exhibit synaptic and glial cell changes, that is characteristic of AD pathology, no evidence of neurodegeneration has been observed. T...
متن کاملInhibition of Amyloid Fibrils Formation from Hen Egg White Lysozyme by Satureia Hortensis Extract and its Effect on Learning and Spatial Memory of Rats
Background & Aims: Alzheimer's disease is a neurodegenerative disorder characterized by the abnormal aggregation of amyloid-β plaques in the brain. Although several studies have been done for finding effective medicines in the treatment of this disease, a drug that inhibits amyloid β aggregation and ameliorates the disorder has not been approved so far. One important therapeutic approach is use...
متن کاملP107: Using Nano Particles as a Novel Application for Alzheimer’s Disease; an Effective Endeavor for Drug Delivery
As the most common cause of dementia among the elderly results in cognitive and ‎behavioral impairment, Alzheimer’s disease (AD) is characterized with aggregation of senile ‎plaques (Beta-amyloid protein), cortical atrophy and ventricular enlargement. Unfortunately, ‎conventional methods like acetyl cholinesterase inhibitor drugs, are not so effective owing to ‎restrictive...
متن کامل